期刊
NEUROSCIENCE LETTERS
卷 389, 期 1, 页码 41-45出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2005.07.004
关键词
cognitive aging; DISC1; hippocampus; association; verbal reasoning
资金
- Biotechnology and Biological Sciences Research Council [S18386] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [S18386] Funding Source: researchfish
DISC1 is expressed in the hippocampus and has been identified as a possible genetic risk factor for both schizophrenia and bipolar disorder. These psychiatric illnesses are associated with impaired learning and memory. This study investigates the association of variation in DISC1 with cognitive function on the same general mental ability test (Moray House Test) at age 11 and age 79, and cognitive change between ages 11 and 79, in 425 people from the Lothian Birth Cohort 1921 (LBC1921). Tests of memory, non-verbal reasoning and executive function were also administered at age 79. The effect of genotype at a non-synonymous single nucleotide polymorphism in exon 11, rs821616, was studied. There was no direct effect of DISC1 genotype on any cognitive measure. However, there was a significant DISC1 genotype by sex interaction on Moray House Test scores at age 79, both before and after adjustment for cognitive ability at age 11 (p=0.034 and 0.043, respectively). Women homozygous for the Cys allele had significantly lower cognitive ability scores than men at age 79, p=0.003. Variation in DISC1 may therefore affect cognitive aging especially in women. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据