期刊
ANNUAL REVIEW OF MEDICINE, VOL 62, 2011
卷 62, 期 -, 页码 347-360出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-med-050109-142444
关键词
anemia; iron overload inflammation
The hepatic peptide hormone hepcidin is the principal regulator of iron absorption and its tissue distribution. Pathologically increased hepcidin concentrations cause or contribute to iron-restrictive anemias including anemias associate with inflammation, chronic kidney disease and some cancers. Hepcidin deficiency results in iron overload in hereditary hemochromatosis and ineffective erythropoiesis. The hepcidin-ferroportin axis is the principal regulator of extracellular iron homeostasis in health and disease, and is a promising target for the diagnosis and treatment of iron disorders and anemias.
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