期刊
ANNUAL REVIEW OF MEDICINE
卷 61, 期 -, 页码 359-373出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.med.60.052907.094936
关键词
quantum dots; Raman scattering; molecular probes; intraoperative imaging; cancer; instrumentation
资金
- US National Cancer Institute Centers of Cancer Nanotechnology Excellence (CCNE) Program [U54CA119338]
- Bioengineering Research Partnerships Program (BRP) [R01CA108468]
- NATIONAL CANCER INSTITUTE [R01CA108468, U54CA119338] Funding Source: NIH RePORTER
Surgery is currently the most effective and widely used procedure in treating human cancers, and the single most important predictor of patient survival is a complete surgical resection. Major opportunities exist to develop new and innovative technologies that could help the surgeon to delineate tumor margins, to identify residual tumor cells and micrometastases, and to determine if the turner his been completely removed. Here we discuss recent advances in nanotechnology and optical instrumentation, and how these advances can be integrated for applications in surgical oncology. A fundamental rationale is that nanometer-sized particles such as quantum dots and colloidal gold have functional and structural properties that are not available from either discrete molecules or bulk materials. When conjugated with targeting ligands such as monoclonal antibodies, peptides, or small molecules, these nanoparticles can be used to target malignant tumor cells and tumor microenvironments with high specificity and affinity. In the mesoscopic size range of 10-100 nm, nanoparticles also have large surface areas for conjugating to multiple diagnostic and therapeutic agents, opening new possibilities in integrated cancer imaging and therapy
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