期刊
ANNUAL REVIEW OF MEDICINE
卷 60, 期 -, 页码 443-456出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.med.60.061907.093117
关键词
complex diseases; genetic association; genomic variation
资金
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [ZIAHG000024] Funding Source: NIH RePORTER
- Intramural NIH HHS [Z99 HG999999] Funding Source: Medline
The International HapMap Project Produced a genome-wide database of genetic Variation for use in genetic association studies of common diseases. The initial output of these studies has been over-whelming, with over 150 risk loci identified in studies of more than 60 common diseases and traits. These associations have Suggested previously unsuspected etiologic pathways for common diseases that will be of use in identifying new therapeutic targets and developing targeted interventions based oil genetically defined risk. Here we examine the development mid application of the HPAMap to genome-wide association (GWA) studies; present and future technologies for CAVA research; Current major efforts in GWA studies; successes and limitations Of the GWA approach in identifying polymorphisms related to complex diseases; data release and privacy polices; use of these findings by Clinicians, the public, and academic physicians; and sources of ongoing authoritative information on this rapidly evolving field.
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