期刊
ANNUAL REVIEW OF MEDICINE
卷 59, 期 -, 页码 61-78出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.med.59.110106.214058
关键词
hypertension in pregnancy; VEGF; sFlt1; endothelial dysfunction
资金
- NHLBI NIH HHS [HL079594] Funding Source: Medline
- NIDDK NIH HHS [DK065997] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL079594] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK065997] Funding Source: NIH RePORTER
Preeclampsia is a systemic syndrome of pregnancy that originates in the placenta and is characterized by widespread maternal endothelial dysfunction. Until recently, the molecular pathogenesis of precclampsia was largely unknown, but recent work suggests a key role for altered expression of placental antiangiogenic factors. Soluble Flt1 and soluble endoglin, secreted by the placenta, are increased in the maternal circulation weeks before the onset of preeclampsia. These antiangiogenic factors produce systemic endothelial dysfunction, resulting in hypertension, proteinuria, and the other systemic manifestations of preeclampsia. The molecular basis for placental dysregulation of these pathogenic factors remains unknown, and the role of angiogenic proteins in early placental vascular development is just beginning to be explored. These discoveries have exciting clinical implications and are likely to transform the detection and treatment of preeclampsia in the future.
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