期刊
JOURNAL OF NEUROSCIENCE
卷 25, 期 48, 页码 11117-11124出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2032-05.2005
关键词
amygdala; hippocampus; startle; skin conductance; fear conditioning; emotion
The present study investigated fear-potentiated startle and autonomic learning in brain- lesioned patients in a classical fear-conditioning paradigm. Startle blink and skin conductance responses of 30 patients who underwent unilateral temporal lobectomy because of drug-resistant epilepsy were compared with those of 32 healthy controls. As expected, temporal lobectomy patients showed a general impairment in fear conditioning relative to controls. This impairment did not differ with respect to the affected hemisphere. Moreover, while fear-conditioned startle potentiation in healthy controls was independent of contingency awareness, skin conductance discrimination was only observed for those participants who correctly recognized the stimulus contingencies. Patients who acquired a declarative memory of the contingencies also showed intact skin conductance discrimination but failed to exhibit fear-potentiated startle. The present findings support a two-levels- of-learning account of human fear conditioning and also demonstrate that the amygdala is crucially involved in fear learning.
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