期刊
JOURNAL OF NEUROSCIENCE METHODS
卷 149, 期 1, 页码 64-73出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneumeth.2005.05.005
关键词
MEG; steady state response; SSR; equivalent-current dipole; auditory
资金
- NIDCD NIH HHS [R01-DC05660] Funding Source: Medline
Complex numbers appear naturally in biology whenever a system can be analyzed in the frequency domain, such as physiological data from magnetoencephalography (MEG). For example, the MEG steady state response to a modulated auditory stimulus generates a complex magnetic field for each MEG channel, equal to the Fourier transform at the stimulus modulation frequency. The complex nature of these data sets, often not taken advantage of, is fully exploited here with new methods. Whole-head, complex magnetic data can be used to estimate complex neural current sources, and standard methods of source estimation naturally generalize for complex sources. We show that a general complex neural vector source is described by its location, magnitude, and direction, but also by a phase and by an additional perpendicular component. We give natural interpretations of all the parameters for the complex equivalent-current dipole by linking them to the underlying neurophysiology. We demonstrate complex magnetic fields, and their equivalent fully complex current sources, with both simulations and experimental data. (c) 2005 Elsevier B.V. All rights reserved.
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