期刊
ANNUAL REVIEW OF IMMUNOLOGY, VOL 32
卷 32, 期 -, 页码 609-634出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-032713-120236
关键词
macrophages; dendritic cells; T cells; metabolism; glycolysis; oxidative phosphorylation; glutaminolysis
类别
资金
- NHLBI NIH HHS [R01 HL076746, HL076746] Funding Source: Medline
- NIAMS NIH HHS [DP1 AR064158, DP1AR064158] Funding Source: Medline
- NIDDK NIH HHS [DK094641, R01 DK081405, R01 DK094641, DK081405, R01 DK101064, R01 DK076760] Funding Source: Medline
The immune system defends against pathogens and maintains tissue homeostasis for the life of the organism. These diverse functions are bioenergetically expensive, requiring precise control of cellular metabolic pathways. Although initial observations in this area were made almost a century ago, studies over the past decade have elucidated the molecular basis for how extracellular signals control the uptake and catabolism of nutrients in quiescent and activated immune cells. Collectively, these studies have revealed that the metabolic pathways of oxidative metabolism, glycolysis, and glutaminolysis preferentially fuel the cell fate decisions and effector functions of immune cells. Here, we discuss these findings and provide a general framework for understanding how metabolism fuels and regulates the maturation of immune responses. A better understanding of the metabolic checkpoints that control these transitions might provide new insights for modulating immunity in infection, cancer, or inflammatory disorders.
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