期刊
ANNUAL REVIEW OF IMMUNOLOGY, VOL 31
卷 31, 期 -, 页码 345-385出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-020711-075041
关键词
autoimmunity; molecular mimicry; blood-brain barrier
类别
资金
- NIAID NIH HHS [P01 AI073693] Funding Source: Medline
Autoimmune diseases currently affect 5-7% of the world's population; in most diseases there are circulating autoantibodies. Brain-reactive antibodies are present in approximately 2-3% of the general population but do not usually contribute to brain pathology. These antibodies penetrate brain tissue only early in development or under pathologic conditions. This restriction on their pathogenicity and the lack of correlation between serum titers and brain pathology have, no doubt, contributed to a delayed appreciation of the contribution of autoantibodies in diseases of the central nervous system. Nonetheless, it is increasingly clear that antibodies can cause damage in the brain and likely initiate or aggravate multiple neurologic conditions; brain-reactive antibodies contribute to symptomatology in autoimmune disease, infectious disease, and malignancy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据