期刊
ANNUAL REVIEW OF IMMUNOLOGY, VOL 30
卷 30, 期 -, 页码 271-294出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-020711-075030
关键词
host-mutualist/commensal/pathogen interactions; immune efficiency; damage control; energetic costs; bribery
类别
资金
- NIAID NIH HHS [AI091068, 1R01AI060164] Funding Source: Medline
- NIH HHS [1DP1OD008167] Funding Source: Medline
A host has two methods to defend against pathogens: It can clear the pathogens or reduce their impact on health in other ways. The first, resistance, is well studied. Study of the second, which ecologists call tolerance, is in its infancy. Tolerance measures the dose response curve of a host's health in reaction to a pathogen and can be studied in a simple quantitative manner. Such studies hold promise because they point to methods of treating infections that put evolutionary pressures on microbes different from antibiotics and vaccines. Studies of tolerance will provide an improved foundation to describe our interactions with all microbes: pathogenic, commensal, and mutualistic. One obvious mechanism affecting tolerance is the intensity of an immune response; an overly exuberant immune response can cause collateral damage through immune effectors and because of the energy allocated away from other physiological functions. There are potentially many other tolerance mechanisms, and here we systematically describe tolerance using a variety of animal systems.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据