期刊
ANNUAL REVIEW OF IMMUNOLOGY, VOL 30
卷 30, 期 -, 页码 357-392出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-020711-075018
关键词
inhibitory receptors; tolerance; autoimmunity; inflammation; clonal ignorance
类别
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI064930, R01AI090867, R01AI076505] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [RC1AR058481] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK043351] Funding Source: NIH RePORTER
- NIAID NIH HHS [AI090867, AI076505, AI064930, R01 AI064930, R01 AI090867, R01 AI076505] Funding Source: Medline
- NIAMS NIH HHS [AR058481, RC1 AR058481] Funding Source: Medline
- NIDDK NIH HHS [P30 DK043351] Funding Source: Medline
Sialic acid-binding Ig-like lectins, or Siglecs, vary in their specificity for sialic acid-containing ligands and are mainly expressed by cells of the immune system. Many Siglecs are inhibitory receptors expressed in innate immune cells that regulate inflammation mediated by damage-associated and pathogen-associated molecular patterns (DAMPs and PAMPs). This family also includes molecules involved in adhesion and phagocytosis and receptors that can associate with the ITAM-containing DAP12 adaptor. Siglecs contribute to the inhibition of immune cells both by binding to cis ligands (expressed in the same cells) and by responding to pathogen-derived sialoglycoconjugates. They can help maintain tolerance in B lymphocytes, modulate the activation of conventional and plasmacytoid dendritic cells, and contribute to the regulation of T cell function both directly and indirectly. Siglecs modulate immune responses, influencing almost every cell in the immune system, and are of relevance both in health and disease.
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