期刊
ANNUAL REVIEW OF IMMUNOLOGY, VOL 30
卷 30, 期 -, 页码 611-+出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-020711-074948
关键词
macroautophagy; virus; bacterial infection; innate immunity; adaptive immunity; xenophagy
类别
资金
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [RC1DK086502, R01DK083756, P30DK043351, R01DK064869, U01DK062432] Funding Source: NIH RePORTER
- NIDDK NIH HHS [RC1 DK086502, P30DK043351, RC1DK086502, R01 DK083756, 5R01DK064869, 5R01DK083756, R01 DK064869, 5U01DK062432] Funding Source: Medline
Stressors ranging from nutrient deprivation to immune signaling can induce the degradation of cytoplasmic material by a process known as autophagy. Increasingly, research on autophagy has begun to focus on its role in inflammation and the immune response. Autophagy acts as an immune effector that mediates pathogen clearance. The roles of autophagy bridge both the innate and adaptive immune systems and include functions in thymic selection, antigen presentation, promotion of lymphocyte homeostasis and survival, and regulation of cytokine production. In this review, we discuss the mechanisms by which autophagy is regulated, as well as the functions of autophagy and autophagy proteins in immunity and inflammation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据