期刊
ANNUAL REVIEW OF IMMUNOLOGY, VOL 30
卷 30, 期 -, 页码 95-114出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-020711-075035
关键词
tolerance; thymic selection; invariant natural killer T cell; intraepithelial lymphocytes; regulatory T cell; natural Th17
类别
资金
- NCI NIH HHS [T32 CA009138] Funding Source: Medline
- NIAID NIH HHS [R01AI39560, R01 AI039560, R37 AI039560] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [T32CA009138] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI039560, R37AI039560] Funding Source: NIH RePORTER
On the whole, the healthy adaptive immune system is responsive to foreign antigens and tolerant to self. However, many individual lymphocytes have, and even require, substantial self-reactivity for their particular functions in immunity. In this review, we discuss several populations of lymphocytes that are thought to experience agonist stimulation through the T cell receptor during selection: nTreg cells, iNKT cells, nIELs, and nTh17s. We discuss the nature of this self-reactivity, how it compares with conventional T cells, and why it is important for overall immune health. We also outline molecular pathways unique to each lineage and consider possible commonalities to their development and survival.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据