期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 78, 期 6, 页码 1192-1197出版社
WILEY
DOI: 10.1189/jlb.0405216
关键词
brain immune modulation; cytokines; marijuana; nitric oxide
资金
- NIDA NIH HHS [R01 DA015608, R01 DA05832, 2P50 DA05274] Funding Source: Medline
Microglia, resident macrophages of the brain, function as immune effector and accessory cells. Paradoxically, they not only play a role in host defense and tissue repair but also have been implicated in a variety of neuropathological processes. Microglia, in addition to exhibiting phenotypic markers for macrophages, express CB1 and CB2 cannabinoid receptors. Recent studies suggest the existence of a third, yet-to-be cloned, non-CB1, non-CB2 cannabinoid receptor. These receptors appear to be functionally relevant within defined windows of microglial activation state and have been implicated as linked to cannabinoid modulation of chemokine and cytokine expression. The recognition that microglia express cannabinoid receptors and that their activation results in modulation of select cellular activities suggests that they may be amenable to therapeutic manipulation for ablating untoward inflammatory responses in the central nervous system.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据