期刊
ANNUAL REVIEW OF IMMUNOLOGY, VOL 29
卷 29, 期 -, 页码 185-214出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-031210-101340
关键词
pattern-recognition receptors; Toll-like receptors; RIG-I-like receptors; autoimmunity; virus
类别
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI072429, R21AI079358, P01AI063302] Funding Source: NIH RePORTER
- NIAID NIH HHS [P01AI063302, R01AI072429, R21AI079358] Funding Source: Medline
Receptors of the innate immune system recognize conserved microbial features and provide key signals that initiate immune responses. Multiple transmembrane and cytosolic receptors have evolved to recognize RNA and DNA, including members of the Toll-like receptor and RIG-I-like receptor families and several DNA sensors. This strategy enables recognition of a broad range of pathogens; however, in some cases, this benefit is weighed against the cost of potential self recognition. Recognition of self nucleic acids by the innate immune system contributes to the pathology associated with several autoimmune or autoinflammatory diseases. In this review, we highlight our current understanding of nucleic acid sensing by innate immune receptors and discuss the regulatory mechanisms that normally prevent inappropriate responses to self.
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