期刊
ANNUAL REVIEW OF IMMUNOLOGY, VOL 29
卷 29, 期 -, 页码 235-271出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-031210-101324
关键词
immunosurveillance; immunoediting; equilibrium; immunotherapy; inflammation; immunosuppression
类别
资金
- Worldwide Cancer Research [08-0577] Funding Source: Medline
The immune system can identify and destroy nascent tumor cells in a process termed cancer immunosurveillance, which functions as an important defense against cancer. Recently, data obtained from numerous investigations in mouse models of cancer and in humans with cancer offer compelling evidence that particular innate and adaptive immune cell types, effector molecules, and pathways can sometimes collectively function as extrinsic tumor-suppressor mechanisms. However, the immune system can also promote tumor progression. Together, the dual host-protective and tumor-promoting actions of immunity are referred to as cancer immunoediting. In this review, we discuss the current experimental and human clinical data supporting a cancer immunoediting process that provide the fundamental basis for further study of immunity to cancer and for the rational design of immunotherapies against cancer.
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