期刊
ANNUAL REVIEW OF IMMUNOLOGY, VOL 29
卷 29, 期 -, 页码 295-317出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-031210-101332
关键词
CTL; escape mutations; NK cells; GWAS; host genetics; viral evolution
类别
资金
- NATIONAL CANCER INSTITUTE [ZIABC010791] Funding Source: NIH RePORTER
- CCR NIH HHS [HHSN261200800001C] Funding Source: Medline
- Intramural NIH HHS Funding Source: Medline
- NCI NIH HHS [HHSN261200800001E] Funding Source: Medline
Multiple epidemiological studies have demonstrated associations between the human leukocyte antigen (HLA) loci and human immunodeficiency virus (HIV) disease, and more recently the killer cell immunoglobulin-like (KIR) locus has been implicated in differential responses to the virus. Genome-wide association studies have convincingly shown that the HLA class I locus is the most significant host genetic contributor to the variation in HIV control, underscoring a central role for CD8 T cells in resistance to the virus. However, both genetic and functional data indicate that part of the HLA effect on HIV is due to interactions between KIR and HLA genes, also implicating natural killer cells in defense against viral infection and viral expansion prior to initiation of an adaptive response. We review the HLA and KIR associations with HIV disease and the progress that has been made in understanding the mechanisms that explain these associations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据