期刊
ANNUAL REVIEW OF IMMUNOLOGY, VOL 28
卷 28, 期 -, 页码 445-489出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-030409-101212
关键词
CD4 effector T cells; regulatory T cells; T cell differentiation; cytokines; transcription factors; human diseases
类别
资金
- Intramural NIH HHS [Z99 AI999999] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZIAAI000493] Funding Source: NIH RePORTER
CD4 T cells play critical roles in mediating adaptive immunity to a variety of pathogens. They are also involved in autoimmunity, asthma, and allergic responses as well as in tumor immunity. During TCR activation in a particular cytokine milieu, naive CD4 T cells may differentiate into one of several lineages of T helper (Th) cells, including Th1, Th2, Th17, and iTreg, as defined by their pattern of cytokine production and function. In this review, we summarize the discovery, functions, and relationships among Th cells; the cytokine and signaling requirements for their development; the networks of transcription factors involved in their differentiation; the epigenetic regulation of their key cytokines and transcription factors; and human diseases involving defective CD4 T cell differentiation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据