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A hypoallergenic hybrid molecule with increased immunogenicity consisting of derivatives of the major grass pollen allergens, PhI p 2 and PhI p 6
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Heterogeneity of commercial timothy grass pollen extracts
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Clinical effects of immunotherapy with genetically modified recombinant birch pollen Bet v 1 derivatives
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CLINICAL AND EXPERIMENTAL ALLERGY (2008)
Different allergenic activity of grass pollen allergens revealed by skin testing
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Variability of IgE reactivity profiles among European mite allergic patients
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EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2008)
Targeting Fel d 1 to FcγRI induces a novel variation of the TH2 response in subjects with cat allergy
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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2008)
Non-IgE-mediated chronic allergic skin inflammation revealed with rBet v 1 fragments
Raffaela Campana et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2008)
The European Union CREATE Project: A model for international standardization of allergy diagnostics and vaccines
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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2008)
Efficacy of recombinant birch pollen vaccine for the treatment of birch-allergic rhinoconjunctivitis
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Several distinct properties of the IgE repertoire determine effector cell degranulation in response to allergen challenge
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Tolerization of a type I allergic immune response through transplantation of genetically modified hematopoietic stem cells
Ulrike Baranyi et al.
JOURNAL OF IMMUNOLOGY (2008)
Assessment of Bet v 1-specific CD4+ T cell responses in allergic and nonallergic individuals using MHC class II peptide tetramers
Laurence Van Overtvelt et al.
JOURNAL OF IMMUNOLOGY (2008)
Intranasal immunization with a dominant T-cell epitope peptide of a major allergen of olive pollen prevents mice from sensitization to the whole allergen
Eva G. Marazuela et al.
MOLECULAR IMMUNOLOGY (2008)
Efficient induction of oral tolerance by fusing cholera toxin B subunit with allergen-specific T-cell epitopes accumulated in rice seed
Hidenori Takagi et al.
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Characterization of a hypoallergenic recombinant Bet v 1 variant as a candidate for allergen-specific immunotherapy
H. Kahlert et al.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2008)
A hypoallergenic vaccine obtained by tail-to-head restructuring of timothy grass pollen profilin, Phl p 12, for the treatment of cross-sensitization to profilin
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Molecular interactions between a recombinant IgE antibody and the β-lactoglobulin allergen
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Analysis of epitope-specific immune responses induced by vaccination with structurally folded and unfolded recombinant bet v 1 allergen derivatives in man
Ines Pree et al.
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The IgE repertoire in PBMCs of atopic patients is characterized by individual rearrangements without variable region of the heavy immunoglobulin chain bias
Annick Lim et al.
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Allergy multivaccines created by DNA shuffling of tree pollen allergens
Michael Wallner et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2007)
Demonstration of circulating allergen-specific CD4+CD25highFoxp3+ T-regulatory cells in both nonatopic and atopic individuals
Laura Maggi et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2007)
Induction of ovalbumin-specific tolerance by oral administration of Lactococcus lactis secreting ovalbumin
Inge L. Huibregtse et al.
GASTROENTEROLOGY (2007)
Costimulation blockade inhibits allergic sensitization but does not affect established allergy in a murine model of grass pollen allergy
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JOURNAL OF IMMUNOLOGY (2007)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Exposure to a farming environment has allergen-specific protective effects on TH2-dependent isotype switching in response to common inhalants
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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2007)
Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data
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Molecular determinants of allergen-induced effector cell degranulation
Anna Gieras et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2007)
Recombinant allergens for immunotherapy
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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2007)
Update on the current status of peptide immunotherapy
Mark Larche
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Antigens drive memory IgE responses in human allergy via the nasal mucosa
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Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis
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NEW ENGLAND JOURNAL OF MEDICINE (2006)
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NATURE REVIEWS IMMUNOLOGY (2006)
The major glycoprotein allergen from Arachis hypogaea, Ara h 1, is a ligand of dendritic cell-specific ICAM-grabbing nonintegrin and acts as a Th2 adjuvant in vitro
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Generation of hypoallergenic DNA vaccines by forced ubiquitination: Preventive and therapeutic effects in a mouse model of allergy
Roman Bauer et al.
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Der p 1 peptide on virus-like particles is safe and highly immunogenic in healthy adults
Thomas M. Kuendig et al.
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Spatial clustering of the IgE epitopes on the major timothy grass pollen allergen Phl p 1: Importance for allergenic activity
S Flicker et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2006)
Induction of interleukin-10 and suppressor of cytokine signalling-3 gene expression following peptide immunotherapy
M Tarzi et al.
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Sublingual immunotherapy with once-daily grass allergen tablets: A randomized controlled trial in seasonal allergic rhinoconjunctivitis
SR Durham et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2006)
Inhibition of rBet v 1-induced basophil histamine release with specific immunotherapy-induced serum immunoglobulin G:: no evidence that FcγRIIB signalling is important
AM Ejrnaes et al.
CLINICAL AND EXPERIMENTAL ALLERGY (2006)
The role of Foxp3+T cells in long-term efficacy of prophylactic and therapeutic mucosal tolerance induction in mice
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Is genetic vaccination against allergy possible?
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INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2006)
IgE-mediated allergen presentation and blocking antibodies: Regulation of T-Cell activation in allergy
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INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2006)
Molecular design of allergy vaccines
B Linhart et al.
CURRENT OPINION IN IMMUNOLOGY (2005)
The effect of Fel d 1-derived T-cell peptides on upper and lower airway outcome measurements in cat-allergic subjects
C Alexander et al.
ALLERGY (2005)
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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2005)
Regulatory activity of human CD4+ CD25+ T cells depends on allergen concentration, type of allergen and atopy status of the donor
I Bellinghausen et al.
IMMUNOLOGY (2005)
Allergen-specific nasal IgG antibodies induced by vaccination with genetically modified allergens are associated with reduced nasal allergen sensitivity
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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2005)
Intranasal tolerance induction with polypeptides derived from 3 noncross-reactive major aeroallergens prevents allergic polysensitization in mice
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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2005)
Biased use of VH5 IgE-positive B cells in the nasal mucosa in allergic rhinitis
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Development of an in vitro system for the study of allergens and allergen-specific immunoglobulin E and immunoglobulin G:: Fcε receptor I supercross-linking is a possible new mechanism of immunoglobulin G-dependent enhancement of type I allergic reactions
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CLINICAL AND EXPERIMENTAL ALLERGY (2005)
A hybrid molecule resembling the epitope spectrum of grass pollen for allergy vaccination
B Linhart et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2005)
A chimeric human-cat fusion protein blocks cat-induced allergy
DC Zhu et al.
NATURE MEDICINE (2005)
T cell epitope immunotherapy induces a CD4+ T cell population with regulatory activity
A Verhoef et al.
PLOS MEDICINE (2005)
Poor association between allergen-specific serum immunoglobulin E levels, skin sensitivity and basophil degranulation:: a study with recombinant birch pollen allergen Bet v 1 and an immunoglobulin E detection system measuring immunoglobulin E capable of binding to FcεRI
A Purohit et al.
CLINICAL AND EXPERIMENTAL ALLERGY (2005)
Antigen presentation of the immunodominant T-cell epitope of the major mugwort pollen allergen, Art v 1, is associated with the expression of HLA-DRB1*01
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Importance of databases in experimental and clinical allergology
A Mari
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2005)
Fel d 1-derived T cell peptide therapy induces recruitment of CD4(+)CD25(+); CD4(+) interferon-gamma(+) T helper type 1 cells to sites of allergen-induced late-phase skin reactions in cat-allergic subjects
C Alexander et al.
CLINICAL AND EXPERIMENTAL ALLERGY (2005)
Dietary prevention of allergic diseases in infants and small children -: Part I:: Immunologic background and criteria for hypoallergenicity
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PEDIATRIC ALLERGY AND IMMUNOLOGY (2004)
Strategies for converting allergens into hypoallergenic vaccine candidates
S Vrtala et al.
METHODS (2004)
VH gene usage in immunoglobulin E responses of seasonal rhinitis patients allergic to grass pollen is oligoclonal and antigen driven
JM Davies et al.
CLINICAL AND EXPERIMENTAL ALLERGY (2004)
Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy decreases the nasal inflammatory response
MK Tulic et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2004)
Non-anaphylactic surface-exposed peptides of the major birch pollen allergen, Bet v 1, for preventive vaccination
M Focke et al.
CLINICAL AND EXPERIMENTAL ALLERGY (2004)
Mechanisms of immunotherapy: IgG revisited
Petra A. Wachholz et al.
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2004)
Genetically engineered negative signaling molecules in the immunomodulation of allergic diseases
Andrew Saxon et al.
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2004)
Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy
MR Karlsson et al.
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Late asthmatic reactions induced by inhalation of allergen-derived T cell peptides
FR Ali et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2004)
Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells
M Akdis et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2004)
A novel approach to specific allergy treatment:: The recombinant fusion protein of a bacterial cell surface (S-layer) protein and the major birch pollen allergen Bet v 1 (rSbsC-Bet v 1) combines reduced allergenicity with immunomodulating capacity
B Bohle et al.
JOURNAL OF IMMUNOLOGY (2004)
Vaccination with genetically engineered allergens prevents progression of allergic disease
V Niederberger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Cat allergen peptide immunotherapy reduces CD4+ T cell responses to cat allergen but does not alter suppression by CD4+ CD25+ T cells:: a double-blind placebo-controlled study
TRF Smith et al.
ALLERGY (2004)
Generation of an allergy vaccine by disruption of the three-dimensional structure of the cross-reactive calcium-binding allergen, Phl p 7
K Westritschnig et al.
JOURNAL OF IMMUNOLOGY (2004)
Formation of disulfide bonds and homodimers of the major cat allergen Fel d 1 equivalent to the natural allergen by expression in Escherichia coli
H Grönlund et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies
N Mothes et al.
CLINICAL AND EXPERIMENTAL ALLERGY (2003)
Renaissance of the blocking antibody concept in type I allergy
S Flicker et al.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2003)
Prevention of allergen-specific IgE production and suppression of an established Th2-type response by immunization with DNA encoding hypoallergenic allergen derivatives of Bet v 1, the major birch-pollen allergen
R Hochreiter et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2003)
Oral administration of specific antigens to allergy-prone infant dogs induces IL-10 and TGF-β expression and prevents allergy in adult life
B Zemann et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2003)
Human CD4+CD25+ T cells derived from the majority of atopic donors are able to suppress TH1 and TH2 cytokine production
I Bellinghausen et al.
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Allergen-specific T-cell tolerance induction with allergen-derived long synthetic peptides: Results of a phase I trial
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Stem cells engineered to express self-antigen to treat autoimmunity
F Alderuccio et al.
TRENDS IN IMMUNOLOGY (2003)
Microarrayed recombinant allergens for diagnosis of allergy
C Harwanegg et al.
CLINICAL AND EXPERIMENTAL ALLERGY (2003)
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A Horst et al.
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R van Ree
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Environmental exposure to endotoxin and its relation to asthma in school-age children
C Braun-Fahrländer et al.
NEW ENGLAND JOURNAL OF MEDICINE (2002)
Gene gun bombardment with gold particles displays a particular Th2-promoting signal that over-rules the Th1-inducing effect of immunostimulatory CpG motifs in DNA vaccines
R Weiss et al.
VACCINE (2002)
Effect of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats:: a randomised controlled trial
WLG Oldfield et al.
LANCET (2002)
Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-Study)
C Möller et al.
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Inhibition of mucosal and systemic Th2-type immune responses by intranasal peptides containing a dominant T cell epitope of the allergen Der p 1
AG Jarnicki et al.
INTERNATIONAL IMMUNOLOGY (2001)
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U Wiedermann et al.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2001)
Late asthmatic reactions provoked by intradermal injection of T-cell peptide epitopes are not associated with bronchial mucosal infiltration of eosinophils or TH2-type cells or with elevated concentrations of histamine or eicosanoids in bronchoalveolar fluid
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Allergen-derived T cell peptide-induced late asthmatic reactions precede the induction of antigen-specific hyporesponsiveness in atopic allergic asthmatic subjects
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FEBS LETTERS (2001)
Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival
J Kalesnikoff et al.
IMMUNITY (2001)
Recombinant allergens with reduced allergenicity but retaining immunogenicity of the natural allergens: Hybrids of yellow jacket and paper wasp venom allergen antigen 5s
TP King et al.
JOURNAL OF IMMUNOLOGY (2001)
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LANCET (2001)
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T cell epitope-containing hypoallergenic recombinant fragments of the major birch pollen allergen, Bet v 1, induce blocking antibodies
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