期刊
ANNUAL REVIEW OF IMMUNOLOGY, VOL 28
卷 28, 期 -, 页码 211-241出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-030409-101218
关键词
allergy; recombinant allergen; specific immunotherapy; IgE; T cell; peptide; diagnosis
类别
资金
- Austrian Science Fund FWF [F 4613] Funding Source: Medline
IgE-mediated allergy is a hypersensitivity disease affecting more than 25% of the population. The structures of the most common allergens have been revealed through molecular cloning technology in the past two decades. On the basis of this knowledge of the sequences and three-dimensional structures of culprit allergens, investigators can now analyze the immune recognition of allergens and the mechanisms of allergic inflammation in allergic patients. Allergy vaccines have been constructed that are able to selectively target the aberrant immune responses in allergic patients via different pathways of the immune system. Here we review various types of allergy vaccines that have been developed based on allergen structures, results from their clinical application in allergic patients, and future strategies for allergen-specific immunotherapy and allergy prophylaxis.
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