期刊
ANNUAL REVIEW OF IMMUNOLOGY
卷 27, 期 -, 页码 363-391出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.immunol.021908.132653
关键词
genome-wide association (GWA) study; interferon; NF-kappa B; autophagy; autoantigen
类别
资金
- National Institutes of Health [AI068759, AR44422, AR12256, AR72232]
- National Arthritis Foundation
- American College of Rheumatology
- Eileen Ludwig Greenland Center for Rheumatoid Arthritis
- Muriel Fusfeld Foundation
- NATIONAL CANCER INSTITUTE [F32CA072232] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR018535] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL012256] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI068759] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [N01AR012256, R01AR044422, N01AR072232] Funding Source: NIH RePORTER
Extraordinary technical advances in the field of human genetics over the post few years have catalyzed an explosion of new information about the genetics of human autoimmunity. In particular, the ability to scan the entire genome for common polymorphisms that associate with disease has led to the identification of numerous new risk genes involved in autoimmune phenotypes. Several themes are emerging. Autoimmune disorders hive a complex genetic basis; multiple genes contribute to disease risk, each with generally modest effects independently. In addition, it is now clear that common genes underlie multiple autoimmune disorders. There is also heterogeneity among subphenotypes within a disease and across major racial groups. The current crop of genetic associations ire only the start of a complete catalog of genetic factors for autoimmunity, and it remains unclear to what extent common variation versus multiple rare variants contribute to disease susceptibility. The current review focuses on recent discoveries within functionally related groups of genes that provide clues to novel pathways of pathogenesis for human autoimmunity.
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