期刊
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 14
卷 14, 期 -, 页码 67-84出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-genom-091212-153515
关键词
chromatin; chromosome territory; enhancer; nuclear periphery; nucleus
资金
- MRC [MC_PC_U127527202] Funding Source: UKRI
- Medical Research Council Funding Source: Medline
- Medical Research Council [MC_PC_U127527202] Funding Source: researchfish
In vivo, the human genome functions as a complex, folded, three-dimensional chromatin polymer. Understanding how the human genome is spatially organized and folded inside the cell nucleus is therefore central to understanding how genes are regulated in normal development and dysregulated in disease. Established light microscopy-based approaches and more recent molecular chromosome conformation capture methods are now combining to give us unprecedented insight into this fascinating aspect of human genomics.
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