期刊
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 14
卷 14, 期 -, 页码 557-577出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-genom-091212-153506
关键词
research ethics; bioethics; biobank; genome sequencing; exome sequencing
资金
- NCI NIH HHS [1-R01-CA154517, R01 CA154517] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA154517] Funding Source: NIH RePORTER
The debate over return of individual research results and incidental findings to study participants is a key frontier in research ethics and practice. This is fundamentally a problem of translational science-a question of when information about an individual that is generated in research should be communicated for clinical attention, particularly as technologies such as whole-genome sequencing and whole-exome sequencing are increasingly used in clinical care. There is growing consensus that investigators should offer participants at least those individual findings of high clinical importance and actionability. Increasing attention to what information biobanks and secondary researchers owe people who provide data and specimens offers an opportunity to treat these source individuals as research partners. Cutting-edge issues include return of results in pediatric populations and return to kin and family, both before and after the death of the proband, as well as how to manage incidental findings in clinical sequencing. Progress will require an understanding of the continuum linking research and clinical care and developing standards and models for return.
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