期刊
JOURNAL OF CLINICAL VIROLOGY
卷 34, 期 -, 页码 S22-S28出版社
ELSEVIER
DOI: 10.1016/S1386-6532(05)80006-X
关键词
Oral fluid; HIV testing; HBV testing; HCV testing
类别
Oral mucosal transudate (OMT) has levels of IgG and IgA that, although lower than in serum, axe of the same specificity as serum. Blood can be a difficult sample to take especially from persons with an aversion to the process or with poor veins. There is also a small exposure risk to the phlebotomist. OMT has been shown to be useful in screening for a range of bloodborne viruses, however, the ELISA assays need to be modified, usually by increasing test volumes and incubation times axld/or by modifying the substrate. A number of commercial serum kits have been modified successfully in this way. The major roles for these assays are for epidemiology or for screening high risk populations. If used for screening, it is imperative that any positive is confirmed by a serum test. The use of OMT samples using the OraSuxe (R) collection device, which is FDA approved and with which we have the most experience, has increased in recent years in community health care settings, with positive feedback from users. (C) 2005 Elsevier B.V. All rights reserved.
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