期刊
THROMBOSIS AND HAEMOSTASIS
卷 94, 期 6, 页码 1122-1130出版社
GEORG THIEME VERLAG KG
DOI: 10.1160/TH05-07-0509
关键词
tissue factor pathway inhibitor-2; tumor; metastasis; mutagenesis; X-ray crystallography
资金
- NHLBI NIH HHS [HL64119] Funding Source: Medline
Tissue factor pathway inhibitor-2 (TFPI-2) is a 32 kDa matrix-associated Kunitz-type serine proteinase inhibitor consisting of a short amino-terminal region,three tandem Kunitz-type domains and a positively charged carboxy-terminal tail. Human TFPI-2, previously designated as placental protein 5, inhibits a broad spectrum of serine proteinases almost exclusively through its first Kunitz-type domain, and is thought to play an important role in the regulation of extracellular matrix digestion and re-modeling. In this context, reduced synthesis of TFPI-2 has been related to numerous pathophysiological processes such as inflammation, angiogenesis, atherosclerosis, retinal degeneration and tumor growth/metastasis. In this review, we document current information regarding the expression of TFPI-2 by various tissues, its inhibitory activity and proteinase specificity in-vitro, and discuss possible physiological roles for this inhibitor based on in-vivo studies.
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