期刊
ANNUAL REVIEW OF GENETICS, VOL 52
卷 52, 期 -, 页码 567-590出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-genet-120417-031513
关键词
IgSF; immunoglobulin superfamily; immune molecules; LAR-RPTPs; MHCI molecules; synapse formation; synaptogenesis
资金
- NIMH NIH HHS [P50 MH106438] Funding Source: Medline
- NINDS NIH HHS [R01 NS060125] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [P50MH106438] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS060125] Funding Source: NIH RePORTER
Synapse formation is mediated by a surprisingly large number and wide variety of genes encoding many different protein classes. One of the families increasingly implicated in synapse wiring is the immunoglobulin superfamily (IgSF). IgSF molecules are by definition any protein containing at least one Ig-like domain, making this family one of the most common protein classes encoded by the genome. Here, we review the emerging roles for IgSF molecules in synapse formation specifically in the vertebrate brain, focusing on examples from three classes of IgSF members: (a) cell adhesion molecules, (b) signaling molecules, and (c) immune molecules expressed in the brain. The critical roles for IgSF members in regulating synapse formation may explain their extensive involvement in neuropsychiatric and neurodevelopmental disorders. Solving the IgSF code for synapse formation may reveal multiple new targets for rescuing IgSF-mediated deficits in synapse formation and, eventually, new treatments for psychiatric disorders caused by altered IgSF-induced synapse wiring.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据