期刊
ANNUAL REVIEW OF GENETICS, VOL 52
卷 52, 期 -, 页码 21-41出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-genet-120417-031404
关键词
epigenetics; transgenerational inheritance; germ cells; development
资金
- NICHD NIH HHS [R01 HD080224] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R01HD080224] Funding Source: NIH RePORTER
Inheritance of genomic DNA underlies the vast majority of biological inheritance, yet it has been clear for decades that additional epigenetic information can be passed on to future generations. Here, we review major model systems for transgenerational epigenetic inheritance via the germline in multicellular organisms. In addition to surveying examples of epivariation that may arise stochastically or in response to unknown stimuli, we also discuss the induction of heritable epigenetic changes by genetic or environmental perturbations. Mechanistically, we discuss the increasingly well-understood molecular pathways responsible for epigenetic inheritance, with a focus on the unusual features of the germline epigenome.
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