期刊
ANNUAL REVIEW OF GENETICS, VOL 48
卷 48, 期 -, 页码 341-359出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-genet-120213-092015
关键词
DNA damage; topoisomerase; somatic hypermutation; class-switch recombination; cytosine deamination
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM057200, R01GM038464, R29GM038464, R01GM093197, R01GM101690] Funding Source: NIH RePORTER
- NIAID NIH HHS [R21 AI144708] Funding Source: Medline
- NIGMS NIH HHS [R01 GM093197, GM101690, GM093197, R01 GM101690, GM057200, R01 GM038464, R01 GM057200, GM038464] Funding Source: Medline
Transcription requires unwinding complementary DNA strands, generating torsional stress, and sensitizing the exposed single strands to chemical reactions and endogenous damaging agents. In addition, transcription can occur concomitantly with the other major DNA metabolic processes (replication, repair, and recombination), creating opportunities for either cooperation or conflict. Genetic modifications associated with transcription are a global issue in the small genomes of microorganisms in which noncoding sequences are rare. Transcription likewise becomes significant when one considers that most of the human genome is transcriptionally active. In this review, we focus specifically on the mutagenic consequences of transcription. Mechanisms of transcription-associated mutagenesis in microorganisms are discussed, as is the role of transcription in somatic instability of the vertebrate immune system.
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