期刊
ANNUAL REVIEW OF GENETICS, VOL 47
卷 47, 期 -, 页码 139-165出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-genet-111212-133424
关键词
posttranscriptional gene regulation; nonsense-mediated mRNA decay; translational repression; quality control; premature termination codon; posttranslational gene regulation; ubiquitin-proteasome system
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM059614] Funding Source: NIH RePORTER
- Howard Hughes Medical Institute Funding Source: Medline
- NIGMS NIH HHS [R01 GM59614, R01 GM059614] Funding Source: Medline
Cells use messenger RNAs (mRNAs) to ensure the accurate dissemination of genetic information encoded by DNA. Given that mRNAs largely direct the synthesis of a critical effector of cellular phenotype, i.e., proteins, tight regulation of both the quality and quantity of mRNA is a prerequisite for effective cellular homeostasis. Here, we review nonsense-mediated mRNA decay (NMD), which is the best-characterized posttranscriptional quality control mechanism that cells have evolved in their cytoplasm to ensure transcriptome fidelity. We use protein quality control as a conceptual framework to organize what is known about NMD, highlighting overarching similarities between these two polymer quality control pathways, where the protein quality control and NMD pathways intersect, and how protein quality control can suggest new avenues for research into mRNA quality control.
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