期刊
ANNUAL REVIEW OF GENETICS, VOL 46
卷 46, 期 -, 页码 617-633出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-genet-110711-155534
关键词
cryptic relatedness; coancestry; IBD mapping; haplotype phase inference; effective population size
资金
- NHGRI NIH HHS [R01HG005701, R01HG004960, R01 HG004960] Funding Source: Medline
- NIGMS NIH HHS [R01GM057091] Funding Source: Medline
Short segments of identity by descent (IBD) between individuals with no known relationship can be detected using genome-wide single nucleotide polymorphism data and recently developed statistical methodology. Emerging applications for the detected IBD segments include IBD mapping, haplotype phase inference, genotype imputation, and inference of population structure. In this review, we explain the principles behind methods for IBD segment detection, describe recently developed methods, discuss approaches to comparing methods, and give an overview of applications.
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