期刊
ANNUAL REVIEW OF GENETICS, VOL 46
卷 46, 期 -, 页码 145-164出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-genet-110711-155514
关键词
behavioral genetics; neurogenetics; complex traits; gene-brain behavior; comparative genomics
资金
- NIAAA NIH HHS [AA016560] Funding Source: Medline
- NIGMS NIH HHS [GM045146, GM076083, GM059469] Funding Source: Medline
Aggression mediates competition for food, mating partners, and habitats and, among social animals, establishes stable dominance hierarchies. In humans, abnormal aggression is a hallmark of neuropsychiatric disorders and can be elicited by environmental factors acting on an underlying genetic susceptibility. Identifying the genetic architecture that predisposes to aggressive behavior in people is challenging because of difficulties in quantifying the phenotype, genetic heterogeneity, and uncontrolled environmental conditions. Studies on mice have identified single-gene mutations that result in hyperaggression, contingent on genetic background. These studies can be complemented by systems genetics approaches in Drosophila melanogaster, in which mutational analyses together with genome-wide transcript analyses, artificial selection studies, and genome-wide analysis of epistasis have revealed that a large segment of the genome contributes to the manifestation of aggressive behavior with widespread epistatic interactions. Comparative genomic analyses based on the principle of evolutionary conservation are needed to enable a complete dissection of the neurogenetic underpinnings of this universal fitness trait.
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