期刊
ANNUAL REVIEW OF GENETICS, VOL 44
卷 44, 期 -, 页码 167-188出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-genet-102209-163523
关键词
small RNA; gene regulation; transcription interference; mRNA stability
资金
- Intramural NIH HHS [ZIA HD001608-19, ZIA HD001608-18] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [ZIAHD001608] Funding Source: NIH RePORTER
Antisense RNAs encoded on the DNA strand opposite another gene have the potential to form extensive base-pairing interactions with the corresponding sense RNA. Unlike other smaller regulatory RNAs in bacteria, antisense RNAs range in size from tens to thousands of nucleotides. The numbers of antisense RNAs reported for different bacteria vary extensively, but hundreds have been suggested in some species. If all of these reported antisense RNAs are expressed at levels sufficient to regulate the genes encoded opposite them, antisense RNAs could significantly impact gene expression in bacteria. Here, we review the evidence for these RNA regulators and describe what is known about the functions and mechanisms of action for some of these RNAs. Important considerations for future research as well as potential applications are also discussed.
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