期刊
ANNUAL REVIEW OF GENETICS
卷 43, 期 -, 页码 305-333出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-genet-102108-134143
关键词
mouse genetics; mutagenesis; phenotype; bioinformatics; ontologies
资金
- Medical Research Council, United Kingdom
- MRC [MC_U142684172, MC_U142684175, MC_U142684171] Funding Source: UKRI
- Medical Research Council [MC_U142684171, MC_U142684175, MC_U142684172] Funding Source: researchfish
The mouse is central to the goal of establishing a comprehensive functional annotation of the mammalian genome that will help elucidate various human disease genes and pathways. The mouse offers a unique combination of attributes, including an extensive genetic toolkit that underpins the creation and analysis of models of human disease. All international effort to generate mutations for every gene in the mouse genome is a first and essential step in this endeavor. However, the greater challenge will be the determination of the phenotype of every mutant. Large-scale phenotyping for genome-wide functional annotation presents numerous scientific, infrastructural, logistical, and informatics; challenges. These include the use of standardized approaches to phenotyping procedures for the population Of unified databases with comparable data sets. The ultimate goal is a comprehensive database of molecular interventions that allows us to create a framework for biological systems analysis in the mouse on which human biology and disease networks can be revealed.
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