期刊
ANNUAL REVIEW OF GENETICS
卷 43, 期 -, 页码 601-625出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.genet.39.073003.114751
关键词
genetic interaction; network; synthetic lethal; Saccharomyces cerevisiae; epistasts
资金
- Canadian Institutes of Health Research [GSP-41567]
- Genome Canada [2004-OGI-3-01]
Genetic interactions influencing a phenotype of interest call be identified systematically using libraries of genetic tools that perturb biological systems in a defined manner. Systematic screens conducted in the yeast Saccharomyces cerevisiae have identified thousands of genetic interactions land provided insight into the global structure of biological networks. Techniques enabling systematic genetic interaction mapping have been extended to other single-celled organisms, the bacteria Escherichia coli and the yeast Schizosaccharomyces pombe, opening the way to comparative investigations of interaction networks. Genetic interaction screens in Caenorhabditis elegans, Drosophila melanogaster and mammalian models are helping to improve our understanding of metazoan-specific signaling pathways. together, our emerging knowledge of the genetic wiring diagrams of eukaryotic and prokaryotic cells is providing a new understanding of the relationship between genotype and phenotype.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据