期刊
ANNUAL REVIEW OF GENETICS
卷 42, 期 -, 页码 269-286出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.genet.42.110807.091656
关键词
transposition; transposon; Tn5; IS50; synaptic complex; target DNA; donor DNA; strand transfer
Tn5 was one of the first transposons to lie identified (10). As a result of Tn5's early discovery and its simple micromolecular requirements for transposition, the Tn5 system has been a very productive tool for studying the molecular mechanism of DNA. transposition. These studies are of broad Value because they offer insights into DNA transposition in general, because DNA transposition is a useful model with which to understand other types of protein-DNA interactions such as retroviral DNA integration and the DNA cleavage events involved in immunoglobulin gene formation, and because Tn5-derived tools are useful adjuncts in genetic experimentation.
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