期刊
NATURE MEDICINE
卷 11, 期 12, 页码 1287-1289出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm1329
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资金
- NIAID NIH HHS [AI47536, AI34786, R01 AI052845, AI52845] Funding Source: Medline
HIV DNA integration is favored in active genes, but the underlying mechanism is unclear. Cellular lens epithelium-derived growth factor (LEDGF/p75) binds both chromosomal DNA and HIV integrase, and might therefore direct integration by a tethering interaction. We analyzed HIV integration in cells depleted for LEDGF/p75, and found that integration was (i) less frequent in transcription units, (ii) less frequent in genes regulated by LEDGF/p75 and (iii) more frequent in GC-rich DNA. LEDGF is thus the first example of a cellular protein controlling the location of HIV integration in human cells.
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