期刊
COMPLEMENTARY THERAPIES IN MEDICINE
卷 13, 期 4, 页码 273-278出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.ctim.2005.07.008
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Objectives: We planned to carry out a pilot study to evaluate the efficacy and safety as an anti hypercholesterolemic agent of a brand dietary supplement made of Monascus purpureus titrated extract, octacosanols and niacin on 111 Caucasian patients with low cardiovascular disease risk (<20% by Framingham algorithms), comparing them with the anti hypercholesterolemic effect of a Low dosage of Pravastatin on 20 subjects with similar risk profile. Results: In our study, the tested dietary supplement determined a significant decrease of Total Cholesterol (TC), Low Density Lipoprotein Cholesterol (LDL-C), and Triglycerides (TG) in moderately hypercholesterolemic subjects without clinically relevant change in Liver and muscular toxicity markers. The reduction of LDL-C reached the 20%, and it is similar to that obtained with a well-known effective statin like Pravastatin. Conclusions: Further long-term and double blind evaluation have to be carried out before to infer the observed results, however it appears that the studied dietary supplements could be a safe and efficacious anti hypercholesterolemic agent for patients at tow risk for cardiovascular diseases. (C) 2005 Elsevier Ltd. All rights reserved.
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