期刊
ANNUAL REVIEW OF GENETICS
卷 42, 期 -, 页码 517-540出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.genet.42.110807.091432
关键词
cell polarity; drosophila; organ patterning; frizzled-pcp signaling; ciliopathies
资金
- NIH/NIGMS
- NIH/NEI
- Deutsche Forschungsgemeinschaft
- NATIONAL EYE INSTITUTE [R01EY013256] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM062917] Funding Source: NIH RePORTER
Most, if not all, cell types and tissues display several aspects of polarization. In addition to the ubiquitous epithelial cell polarity along the apical-basolateral axis, many epithelial tissues and organs are also polarized within the plane of the epithelium. This is generally referred to as planar cell polarity PCP; or historically, tissue polarity. Genetic screens in Drosophila pioneered the discovery of core PCP factors, and subsequent work in vertebrates has established that the respective pathways are evolutionarily conserved. PCP is not restricted only to epithelial tissues but is also found in mesenchymal cells, where it can regulate cell migration and cell intercalation. Moreover, particularly in vertebrate the conserved core PCP signaling factors have recently been found to be associated with the orientation or formation of cilia. This review discusses new developments in the molecular understanding of PCP establishment in Drosophila and vertebrates; these developments are integrated with new evidence that links PCP signaling to human disease.
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