期刊
ANNUAL REVIEW OF GENETICS
卷 42, 期 -, 页码 335-359出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.genet.42.110807.091620
关键词
mitosis; chromosome segregation; microtubule; kinetochore; centromere
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM032238] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM032238, R01 GM032238-21] Funding Source: Medline
Accurate segregation of duplicated chromosomes ensures that daughter cells get one and only one copy of each chromosome. Errors ill chromosome segregation result ill aneuploidy and have severe consequences on human health. Incorrect chromosome number and chromosomal instability are hallmarks of tumor cells. Hence, segregation errors are thought to be a Major Cause of tumorigenesis. A study of the physical mechanical basis of chromosome segregation is essential to understand the processes that call lead to errors. Tremendous progress has been made in recent years in identifying the proteins necessary for chromosome movement and segregation, but the mechanism and structure of critical force generating components and the molecular basis of centrosome stiffness remain poorly understood.
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