期刊
MOLECULAR AND CELLULAR BIOLOGY
卷 25, 期 23, 页码 10479-10491出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.25.23.10479-10491.2005
关键词
-
Placental development initially occurs in a low-oxygen (O-2) or hypoxic environment. In this report we show that two hypoxia-inducible factors (HIFs), HIF alpha and HIF2 alpha, are essential for determining murine placental cell fates. HIF is a heterodimer composed of HIF alpha and HIF beta (ARNT) subunits. Placentas from Arnt(-/-) and Hif1 alpha(-/-) Hif2 alpha(-/-) embryos exhibit defective placental vascularization and aberrant cell fate adoption. HIF regulation of Mash2 promotes spongiotrophoblast differentiation, a prerequisite for trophoblast giant cell differentiation. In the absence of Arnt or Hif alpha, trophoblast stem cells fail to generate these cell types and become labyrinthine trophoblasts instead. Therefore, HIF mediates placental morphogenesis, angiogenesis, and cell fate decisions, demonstrating that O-2, tension is a critical regulator of trophoblast lineage determination. This novel genetic approach provides new insights into the role of O-2, tension in the development of life-threatening; pregnancy-related diseases such as preeclampsia.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据