期刊
DRUG RESISTANCE UPDATES
卷 8, 期 6, 页码 359-368出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.drup.2005.12.001
关键词
apoptosis; caspases; IAP; IBM; bortezomib; bcl-2 mitochondria; death receptors; apoptosome; hsp; p53; NF-kappa B; noxa; Mcl-1; ubiquitin; proteasome
The promising effects of the proteasome inhibitor bortezomib (Veleade, PS-341) in the treatment of certain types of cancer have fired up the interest on this multicatalytic proteolytic machinery. A number of recent reviews thoroughly describe various aspects of the ubiquitin-proteasome system and its importance in the control of cell growth and tumorigenesis. Here, we will focus on recent data unveiling a link between the proteasome and some elements of the apoptotic machinery including Bcl-2 members, caspases, IAPs and IAP antagonists. Perturbing their turnover significantly contributes to the apoptotic response and the anti-neoplastic activity of proteasome inhibitors. (C) 2005 Elsevier Ltd. All rights reserved.
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