期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 62, 期 23, 页码 2867-2876出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-005-5289-7
关键词
mast cell; histamine; tryptase; TNF-alpha; tissue remodeling; proliferation; calcium
Fibroblast proliferation is a key process in tissue remodeling and mast cells (MCs) are thought to play a crucial role. Having established that the three major MC products, tryptase, histamine and TNF-alpha (TNF) are normally present in human skin MCs, which are in close proximity to dermal fibroblasts, we studied their individual effects on cell cycle-controlled human dermal fibroblasts (HFFF2). These cells express receptors (H1, PAR2, TNFR1/2) for the major MC mediators, but only tryptase or a PAR2 agonist peptide stimulated proliferation and gene expression. TNF was antimitotic, and histamine, while elevating intracellular Ca2+ levels at high concentrations, did not affect proliferation. We conclude that MC products but also composition and numbers of respective receptors on fibroblasts are crucially responsible for fibroproliferative events.
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