期刊
NATURE METHODS
卷 2, 期 12, 页码 951-953出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH805
关键词
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资金
- NIAID NIH HHS [R21 AI057713, R01 AI38166] Funding Source: Medline
- NIDDK NIH HHS [P30 DK52574, R01 DK63041] Funding Source: Medline
We developed a microarray hybridization-based method, 'comparative genome sequencing' (CGS), to find mutations in bacterial genomes and used it to study metronidazote resistance in H. pylori. CGS identified mutations in several genes, most likely affecting metronidazole activation, and produced no false positives in analysis of three megabases. We conclude that CGS identifies mutations in bacterial genomes efficiently, should enrich understanding of systems biology and genome evolution, and help track pathogens during outbreaks.
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