期刊
ANNUAL REVIEW OF ECOLOGY, EVOLUTION, AND SYSTEMATICS, VOL 45
卷 45, 期 -, 页码 179-201出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-ecolsys-120213-091846
关键词
Fisher's geometric model; adaptive landscape; distribution of fitness effects; epistasis; pleiotropy; phenotypic complexity; robustness; drift load
资金
- European Research Council [310944] Funding Source: Medline
The accumulation of data on the genomic bases of adaptation has triggered renewed interest in theoretical models of adaptation. Among these models, Fisher's geometric model (FGM) has received a lot of attention over the past two decades. FGM is based on a continuous multidimensional phenotypic landscape, but it is mostly used for the emerging properties of individual mutation effects. Despite its apparent simplicity and limited number of parameters, FGM integrates a full model of mutation and epistatic interactions that allows the study of both beneficial and deleterious mutations and, subsequently, the fate of evolving populations. In this review, I present the different properties of FGM and the qualitative and quantitative support they have received from experimental evolution data. I then discuss how to estimate the different parameters of the model and outline some future directions to connect FGM and the molecular determinants of adaptation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据