期刊
MATERIALWISSENSCHAFT UND WERKSTOFFTECHNIK
卷 36, 期 12, 页码 761-767出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mawe.200500961
关键词
tissue engineering; scaffold; anisotropic pore structure; hydrogel; hydroxyapatite; ionotropic gelation
Porous and mineralised scaffolds are required for various applications in hard tissue engineering. Scaffolds with oriented tube-like pores facilitate homogenous cell seeding, a sufficient nutrient supply during cell culture (even in big constructs) and a fast vascularisation after implantation. The phenomenon of ionotropic gelation has been known since more than 30 years which describes that alginate forms gels with capillary-like pores when covered with solutions of di- or trivalent cations [1]. This technique has been used here to develop scaffolds with tube-like and regular pores from alginate/calcium phosphate composites and to stabilise them by mineralisation with hydroxyapatite from solution.
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