期刊
EMERGING INFECTIOUS DISEASES
卷 11, 期 12, 页码 1828-1834出版社
CENTER DISEASE CONTROL
DOI: 10.3201/eid1112.050898
关键词
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资金
- NIAID NIH HHS [R01 AI044102, R01 AI041213, R01 AI44102, R01 AI41213] Funding Source: Medline
- NINDS NIH HHS [R21 NS050711] Funding Source: Medline
Human granulocytic anaplasmosis is a tickborne rickettsial infection of neutrophils caused by Anaplasma phagocytophilum. The human disease was first identified in 1990, although the pathogen was defined as a veterinary agent in 1932. Since 1990, US cases have markedly increased, and infections are now recognized in Europe. A high international seroprevalence suggests infection is widespread but unrecognized. The niche for A. phagocytophilum, the neutrophil, indicates that the pathogen has unique adaptations and pathogenetic mechanisms. Intensive study has demonstrated interactions with hostcell signal transduction and possibly eukaryotic transcription. This interaction leads to permutations of neutrophil function and could permit immunopathologic changes, severe disease, and opportunistic infections. More study is needed to define the immunology and pathogenetic mechanisms and to understand why severe disease develops in some persons and why some animals become long-term permissive reservoir hosts.
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