期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 69, 期 12, 页码 2312-2318出版社
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.69.2312
关键词
insulin-dependent diabetes mellitus; non-obese diabetic mouse; sex difference; glutamic acid decarboxylase; interferon-gamma
Non-obese diabetic (NOD) mice spontaneously develop type 1 diabetes with a strong female predilection. Using co-culture systems with both female and male spleen cells, we found that spleen cells derived from male NOD mice suppress autoantigen (glutamic acid decarboxylase) induced production of interferon-gamma of female cells in vitro. In addition, this suppression appeared to be mediated by a soluble factor(s) produced by male cells in response to the same antigen. Our experimental systems might be useful for further understanding sex differences in autoimmunity as well as in the basic immune response.
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