期刊
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 34
卷 34, 期 -, 页码 137-162出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-cellbio-100617-062802
关键词
ubiquitin; monoubiquitylation; ubiquitin chain; branched ubiquitin chain; proteasome
资金
- Howard Hughes Medical Institute Funding Source: Medline
- NIGMS NIH HHS [F32 GM123716] Funding Source: Medline
Ubiquitylation is an essential posttranslational modification that controls cell division, differentiation, and survival in all eukaryotes. By combining multiple E3 ligases (writers), ubiquitin-binding effectors (readers), and de-ubiquitylases (erasers) with functionally distinct ubiquitylation tags, the ubiquitin system constitutes a powerful signaling network that is employed in similar ways from yeast to humans. Here, we discuss conserved principles of ubiquitin-dependent signaling that illustrate how this posttranslational modification shapes intracellular signaling networks to establish robust development and homeostasis throughout the eukaryotic kingdom.
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