期刊
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30
卷 30, 期 -, 页码 393-415出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-cellbio-101011-155831
关键词
cytoplasmic polyadenylation element binding protein; CPEB; Orb; translation; polyadenylation; development; cancer; learning and memory
资金
- Canadian Institutes of Health Research [MOP-44050, ISP-108811] Funding Source: Medline
- NIGMS NIH HHS [GM46779] Funding Source: Medline
- NINDS NIH HHS [NS79415] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM046779] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS079415] Funding Source: NIH RePORTER
The cytoplasmic polyadenylation element binding (CPEB) proteins are sequence-specific mRNA binding proteins that control translation in development, health, and disease. CPEB1, the founding member of this family, has become an important model for illustrating general principles of translational control by cytoplasmic polyadenylation in gametogenesis, cancer etiology, synaptic plasticity, learning, and memory. Although the biological functions of the other members of this protein family in vertebrates are just beginning to emerge, it is already evident that they, too, mediate important processes, such as cancer etiology and higher cognitive function. In Drosophila, the CPEB proteins Orb and Orb2 play key roles in oogenesis and in neuronal function, as do related proteins in Caenorhabditis elegans and Aplysia. We review the biochemical features of the CPEB proteins, discuss their activities in several biological systems, and illustrate how understanding CPEB activity in model organisms has an important impact on neurological disease.
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