期刊
NATURE METHODS
卷 2, 期 12, 页码 941-950出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH820
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资金
- NIDA NIH HHS [R21 DA017895-01, R21 DA017895] Funding Source: Medline
- NINDS NIH HHS [R01 NS050533-01, R01 NS050533] Funding Source: Medline
Optical fibers guide light between separate Locations and enable new types of fluorescence imaging. Fiber-optic fluorescence imaging systems include portable handheld microscopes, flexible endoscopes well suited for imaging within hollow tissue cavities and microendoscopes that allow minimally invasive high-resolution imaging deep within tissue. A challenge in the creation of such devices is the design and integration of miniaturized optical and mechanical components. Until recently, fiber-based fluorescence imaging was mainly limited to epifluorescence and scanning confocal modalities. Two new classes of photonic crystal fiber facilitate ultrashort pulse delivery for fiber-optic two-photon fluorescence imaging. An upcoming generation of fluorescence imaging devices will be based on microfabricated device components.
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